02481cam a22002654a 4500 100602s2011 flua b 001 0 eng 9781439825488 SDU R853 B534 2011 Bayesian adaptive methods for clinical trials / Scott M. Berry ... [et al.]. Boca Raton : CRC Press, 2011. 305 p. : ill. Chapman & Hall/CRC biostatistics series ; 38 Statistical approaches for clinical trials -- Basics of Bayesian inference -- Phase I studies -- Phase II studies -- Phase III studies -- Special topics. HKBU library YT2025 M08 "As has been well-discussed, the explosion of interest in Bayesian methods over the last 10 to 20 years has been the result of the convergence of modern computing power and ełcient Markov chain Monte Carlo (MCMC) algo- rithms for sampling from and summarizing posterior distributions. Prac- titioners trained in traditional, frequentist statistical methods appear to have been drawn to Bayesian approaches for three reasons. One is that Bayesian approaches implemented with the majority of their informative content coming from the current data, and not any external prior informa- tion, typically have good frequentist properties (e.g., low mean squared er- ror in repeated use). Second, these methods as now readily implemented in WinBUGS and other MCMC-driven software packages now oʼer the simplest approach to hierarchical (random eʼects) modeling, as routinely needed in longitudinal, frailty, spatial, time series, and a wide variety of other settings featuring interdependent data. Third, practitioners are attracted by the greater ʻexibility and adaptivity of the Bayesian approach, which permits stopping for ełcacy, toxicity, and futility, as well as facilitates a straightforward solution to a great many other specialized problems such as dose-nding, adaptive randomization, equivalence testing, and others we shall describe. This book presents the Bayesian adaptive approach to the design and analysis of clinical trials"--Provided by publisher. Clinical trials Statistical methods. 194133 Bayesian statistical decision theory. Clinical Trials as Topic. 112900 Bayes Theorem. 194134 Berry, Scott M. 194135 32450 = C.1 ศูนย์วิทยาศาสตร์ GBE lcc 104256 104256 0 0 lcc 0 R0853 B534 02011 0 CGB 278684 SC SC GEN 2025-08-21 2 R853 B534 2011 1000365637 2025-08-21 00:00:00 C.1 2025-08-21 GBE