02592cam a2200265 a 4500008004100000020001800041020001500059040000800074050001900082245015400101260003600255300001900291490006500310505169700375505001702072518001502089650002502104650002202129650003102151650003302182650002002215650003402235650003202269700002502301110927s2012    njua     b    001 0 eng    a9780470170830  a0470170832  aSDU00aR853bP74 201200aPredictive approaches in drug discovery and development :bbiomarkers and in vitro/in vivo correlations /cedited by J. Andrew Williams ... [et al.].  aHoboken, N.J. :bWiley,c2012 .  a387 p. :bill.1 aWiley series on technologies for the pharmaceutical industry0 aThe importance of biomarkers in translational medicine / Joseph Fleishaker -- Fit for purpose validation of biochemical assays : challenges and solutions / Gabriella Szekely-Klepser and Scott Fountain -- Transcriptional profiling in biomarker discovery / Michael E. Burczynski ... [et al.] -- Proteomic biomarker approaches in drug discovery and development / Ruth A. Vanbogelen, Jeffrey D. Thomas, and Diane Alessi -- Application of metabolomics to pharmaceutical research and development / Qiuwei Xu and William H. Schaefer -- Vascular biomarkers and imaging studies / Karin Potthoff, Ulrike Fiedler, and Joachim Drevs -- Cardiovascular biomarkers as examples of success and failure in predicting safety in humans / Simon Authier ... [et al.] -- Use of molecular imaging for receptor occupancy decision making in drug development / R. Paul Maguire -- Biosensors for clinical biomarkers / Sara Tombelli and Marco Mascini -- US regulatory perspective on biomarker development / Rajnikath Madabushi, Lawrence Lesko, and Janet Woodcock -- EU regulatory perspective on biomarkers / Ian Hudson -- Use of biomarkers in drug development : Japanese perspectives / Yoshiaki Uyama ... [et al.] -- In vitro-in vivo correlations of hepatic drug clearance / R. Scott Obach -- The potential of in silico and in vitro approaches to predict in vivo drug-drug interactions and ADMET/TOX properties / Kenneth Bachmann and Sean Ekins -- In vitro-in vivo correlations in drug discovery and development : concepts and applications in toxicology / Rex Denton, Kimberly Brannen, and Buce D. Car -- Assessing the potential for induction of cytochrome P450 enzymes and predicting the in vivo response / Jiunn H. Lin.0 aHKBU library  aYT2025 M08 0aBiochemical markers. 0aDrug development. 0aPharmaceutical technology.12aBiomarkers, Pharmacological.12aDrug Discovery.22aDrug Evaluation, Preclinical.22aTechnology, Pharmaceutical.1 aWilliams, J. Andrew.