02488cam a22002417a 4500008004100000020001500041020001800056040000800074050002100082245008300103260005200186300001900238490004400257505001700301520156300318650004801881650003701929700003001966900006501996942001302061999001902074952015302093110504s2011    ne a     bf   001 0 eng d  a1607507323  a9781607507321  aSDU00aRC523bH236 201100aHandbook of animal models in Alzheimer's disease /cedited by Gemma Casadesus.  aAmsterdam ;aWashington DC :bIOS Press,c2011.  a340 p. :bill.1 aAdvances in Alzheimer's disease ;vv. 1  aHKBU library  aAnimals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals - including transgenic animals - has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease. 0aAlzheimer's diseasexAnimal models.9212829 0aDiseasesxAnimal models.92128301 aCasadesus, Gemma.9212831  a33069 = C.1 ศูนย์วิทยาศาสตร์  cGBE2lcc  c110038d110038  00102lcc406RC0523 H236  02011708CGB9278044aSCbSCcGENd2025-08-14e2oRC523 H236 2011p1000365210r2025-08-14 00:00:00tC.1w2025-08-14yGBE