000			02323cam a22002297a 4500
008			110504s2011 ne a bf 001 0 eng d
020			_a1607507323
020			_a9781607507321
040			_aSDU
050	0	0	_aRC523 _bH236 2011
245	0	0	_aHandbook of animal models in Alzheimer's disease / _cedited by Gemma Casadesus.
260			_aAmsterdam ; _aWashington DC : _bIOS Press, _c2011.
300			_a340 p. : _bill.
490	1		_aAdvances in Alzheimer's disease ; _vv. 1
505			_aHKBU library
520			_aAnimals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals - including transgenic animals - has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.
650		0	_aAlzheimer's disease _xAnimal models. _9212829
650		0	_aDiseases _xAnimal models. _9212830
700	1		_aCasadesus, Gemma. _9212831
900			_a33069 = C.1 ศูนย์วิทยาศาสตร์
942			_cGBE _2lcc
999			_c110038 _d110038